Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates

Cliffs: 645 subjects were split into four groups that varied macronutrient composition, but each was in a 750 calorie deficit. 

The diets were based on percentage of calories (fat/carbohydrate/protein)

Group 1 – 20/15/65

Group 2 – 20/25/55

Group 3 – 40/15/45

Group 4 – 40/25/35

Despite a wide variety of macronutrient composition, there was no significant difference in weight loss between groups. 

Take home point: Calories are the main culprit of weight loss or gain. For long term success it's ideal to find a macronutrient composition that's most easily adhered to for each individual.